Scale-up and optimization of filtration processes: Pressure filter to centrifuge

N.A. Mitchell*, S.K. Bermingham, Process Systems Enterprise (PSE) Ltd, UK; C. L. Burcham, C.S. Polster, Eli Lilly and Company; K.P. Girard, Pfizer Inc., USA

The separation of solid particles from liquids via filtration is a key unit operation in the pharmaceutical sector. This processing step commonly occurs after the isolation of an Active Pharmaceutical Ingredient (API) via crystallization and may involve a number of wash cycles in order to deliqour the cake and remove any residual solvents below specified limits. For the purposes of filtration, pressure or vacuum filters and centrifuges are most commonly employed.

In this work we detail a model based workflow for the scale-up of filtration unit operations...

Session: L5 - Cake Filtration III - Scale-up and Optimization
Day: 11 October 2016
Time: 16:45 - 18:00 h